cloud
VHP4Safety Cloud Services
VHP4Safety needs a cloud with a high diversity of services to support their case studies. The services will run on (interal) but also outside (external) the VHP4Safety cloud, on a case by case basis.
This webpage gives an overview of the VHP4Safety Cloud Services on the Production and Development platforms. The second is where we develop and test cloud services, while the first runs a stable version of the service.
Below you find an overview of services available in the context of the VHP4Safety Platform. Additional services have been suggested and users can request additional services.
Cloud catalog
The VHP4Safety Cloud catalog of potential, internal, and external services is available here.
VHP4Safety Platform
The current development platform runs several services.
AOP-Wiki Snorql UI
Graphical interface to an AOP-Wiki SPARQL endpoint. [more info]
BridgeDb
A framework to map identifiers between various biological databases and related sources. [more info]
CDK Depict
A webservice that converts a SMILES into 2D depictions (SVG or PNG). [more info]
cpLogD
A model to predict water–octanol distribution coefficient (logD) for chemical compounds. It is a proxy for the lipophilicity which is a major determinant of drug properties and overall suitability of drug candidates. [more info]
VHP4Safety Wikibase User Interface
A Synia-based graphical user interface to the content of the VHP4Safety Wikibase using SPARQL queries. [more info]
SOM Prediction
A webservice for protein-structure and reactivity based (P450) site-of-metabolism prediction. [more info]
xploreaop
Shiny webapplication to visualize Adverse Outcome Pathway (AOP) networks. So far data has been included to interactively explore the AOPs for two liver outcomes: Cholestasis and Steatosis [more info]
External Services
PopGen
Service to generate online virtual human population. [more info]
QSPRpred
Service to train and employ QSAR and PCM models. Takes a compound structure and pretrained model as input and returns the predicted potency of said compound. [more info]
SysRev
Service to support literature research. [more info]
TXG-MAPr
An R-Shiny-based implementation of weighted gene co-expression network analysis (WGCNA) obtained from the Primary Human Hepatocytes (PHH) TG-GATEs dataset. [more info]
VHP4Safety Wikibase
A Wikibase instance to hold information about compounds. [more info]
WikiPathways - AOP Portal
This Adverse Outcome Pathway (AOP) portal for WikiPathways to highlight the molecular basis of AOPs or events in AOPs. [more info]
Funding
VHP4Safety – the Virtual Human Platform for safety assessment project NWA 1292.19.272 is part of the NWA research program ‘Research along Routes by Consortia (ORC)’, which is funded by the Netherlands Organization for Scientific Research (NWO). The project started on June 1, 2021 with a budget of over 10 million Euros and will last for the duration of 5 years.